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August 18, 2025Open Access

Glycosylated extracellular matrix drives immune suppression by controlling T cell movement, macrophage phenotype, and macrophage-T cell crosstalk in triple negative breast cancer

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Authors

OPOliver M.T. PearceETEleanor J. TylerYLYing Liu

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Overview

Comprehensive profiling reveals that ECM glycan modifications alter immune cell dynamics in triple negative breast cancer, suggesting new therapeutic strategies.

Key Points

  • Glycan modifications in the extracellular matrix suppress anti-tumor immunity and enhance tumor progression.
  • Post-translational changes impacted T cell and macrophage interactions, leading to macrophage activation and reduced T cell exhaustion.
  • Using decellularized TNBC samples, targeted removal of ECM glycans shifted myeloid cells towards activation and restored T cell infiltration.
  • Findings indicate ECM glycosylation as a critical regulatory mechanism in the tumor microenvironment, with therapeutic implications.

Cite This Study

Pearce et al. (2025) studied this question.

synapsesocial.com/papers/68af2ef6cf1dd9ea359e714bhttps://doi.org/10.21203/rs.3.rs-7375429/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Role of Tumor Microenvironment in Triple-Negative Breast Cancer and Its Therapeutic Targeting2025
  2. 2ECM-Induced IL-23 Drives Immune Suppression in Breast Cancer via Regulating PD-1 on Tregs2025
  3. 3Biophysical Properties of the Extracellular Matrix in Cancer: Insights Into Immunotherapy2025
  4. 4Key players in the breast cancer microenvironment: From fibroblasts to immune cells2025
  5. 5Roles of tumor-associated macrophages in triple-negative breast cancer progression2025