Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 29, 2025Cell Communication and SignalingOpen Access

The mechanobiology of extracellular matrix: a focus on thrombospondins

View Full Paper
Ask AI
Bookmark
Share

Authors

YZYing‐Yong ZhaoTLTing LeiXGXin Ge

Discussion

Loading...

Member takes

Overview

Review highlights thrombospondins' roles in cardiovascular homeostasis and their implications for fibrosis and tumorigenesis.

Key Points

  • Thrombospondins (TSPs) play a key role in transducing mechanical cues into biochemical signals during cardiovascular processes.
  • Mechanical stimuli regulate TSP expression, influencing cellular responses in various tissues linked to disease.
  • Under pathological conditions, TSP-1 activation is associated with cardiovascular diseases like atherosclerosis and hypertension.
  • Targeting TSP-receptor interfaces presents novel therapeutic avenues for treating mechanopathologies and enhancing regeneration.

Cite This Study

Zhao et al. (2025) studied this question.

synapsesocial.com/papers/689a093fe6551bb0af8cec2ehttps://doi.org/10.1186/s12964-025-02365-y
View Full Paper
Ask AI
Bookmark
Share