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August 1, 2025FEBS JournalOpen Access

Principal mechanisms of extracellular matrix‐mediated cell–cell communication in physiological and tumor microenvironments

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Authors

ZPZoi PiperigkouSMSylvia ManganiNKNikolaos E. Koletsis

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Overview

This review explores how extracellular matrix dynamics influence cell communication in tumor microenvironments, suggesting new therapeutic avenues.

Key Points

  • Extracellular matrix plays a pivotal role in regulating cell communication in both physiological and pathological states.
  • Biomechanical properties of the ECM influence vital processes like signaling, adhesion, and cell migration in cancer.
  • Extracellular vesicles facilitate communication by transporting proteins and microRNAs between cells, impacting tumor progression.
  • Targeting ECM components could be a promising approach for developing new treatments for cancer and related disorders.

Cite This Study

Piperigkou et al. (2025) studied this question.

synapsesocial.com/papers/689a0c6be6551bb0af8cfcfehttps://doi.org/10.1111/febs.70207
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