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September 21, 2025Infectious Diseases and TherapyOpen Access

Optimizing Polymyxin B Therapy in Critical Care: Pharmacokinetic Insights and Clinical Outcomes in a Retrospective Cohort Study

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Authors

QPQ. PengQLQing LiMXMaggie Xiong

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Overview

Retrospective cohort study investigates polymyxin b therapy outcomes in critically ill patients, indicating significant mortality correlations.

Key Points

  • The study revealed a 28-day mortality rate of 43.2% in patients treated with polymyxin b.
  • Multivariable analysis indicated that polymyxin b pharmacokinetic parameters are associated with mortality outcomes.
  • Logistic regression demonstrated that baseline eGFR and duration of treatment are key risk factors for acute kidney injury.
  • An AUCss, 24 h threshold of 81.6 mg·h/l may help predict patient mortality during polymyxin b therapy.

Cite This Study

Peng et al. (2025) studied this question.

synapsesocial.com/papers/68d43c8e713b0b5dfea7c83chttps://doi.org/10.1007/s40121-025-01213-3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The association between acute kidney injury and Polymyxin B treatment: A retrospective cohort study2025
  2. 2Optimizing polymyxin B exposure in carbapenem-resistant organism Hospital-Acquired Pneumonia: a retrospective observational study2025
  3. 3Comparative outcomes of polymyxins in neurocritical care patients with carbapenem-resistant Gram-negative bacterial pneumonia: a retrospective cohort study2025
  4. 4P04 Low-dose polymyxin B is non-inferior to conventional doses in dialysis dependent and non-dialysis patients with Gram-negative sepsis: a real-world propensity-score matched cohort study2025
  5. 5Safety and therapeutic potential evaluation of Cefotaxime plus Polymyxin B against polymyxin-carbapenem resistant Klebsiella pneumoniae in a murine model2026