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September 19, 2025Science ProgressOpen Access

The association between acute kidney injury and Polymyxin B treatment: A retrospective cohort study

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Authors

LWLong WenXYXuefeng YuanXLXiaohui Liu

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Overview

Retrospective analysis shows potential nephrotoxicity of polymyxin B in patients with AKI, suggesting risks with higher dosing.

Key Points

  • The occurrence of acute kidney injury (AKI) was noted in 42.9% of patients treated with polymyxin B.
  • Patients with concurrent chronic kidney disease had a significantly higher risk for AKI with an odds ratio of 5.47.
  • Individuals receiving higher daily maintenance doses of polymyxin B also faced increased risk for AKI, indicating dose-dependent nephrotoxicity.
  • Regular monitoring of renal function during polymyxin B treatment is crucial to mitigate nephrotoxic effects.

Cite This Study

Wen et al. (2025) studied this question.

synapsesocial.com/papers/68d436fd713b0b5dfea7686bhttps://doi.org/10.1177/00368504251379362
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Optimizing Polymyxin B Therapy in Critical Care: Pharmacokinetic Insights and Clinical Outcomes in a Retrospective Cohort Study2025
  2. 2Acute kidney injury of intravenous colistin sulfate compared with colistimethate sodium: a real-world, retrospective cohort study2025 · 6 citations
  3. 3Optimizing polymyxin B exposure in carbapenem-resistant organism Hospital-Acquired Pneumonia: a retrospective observational study2025
  4. 4Safety and therapeutic potential evaluation of Cefotaxime plus Polymyxin B against polymyxin-carbapenem resistant Klebsiella pneumoniae in a murine model2026
  5. 5Case Report: Polymyxin E-associated reversible leukopenia.2025