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September 10, 2025Probiotics and Antimicrobial ProteinsOpen Access

Effects of Probiotic and Synbiotic Supplementation on Glycemic Indices in Adult Individuals with Prediabetes and Type 2 Diabetes Mellitus: A Grade-Assessed Systematic Review and Dose–Response Meta-analysis of RCTs

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Authors

ASAzin SetayeshMKMehdi KarimiMKMohammad Amin Karimi

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Overview

Systematic review shows probiotics effectively lower glycemic indices in individuals with prediabetes and type 2 diabetes mellitus, suggesting adjunctive benefits.

Key Points

  • Probiotic and synbiotic supplementation significantly reduced fasting blood glucose levels by 7.00 mg/dL.
  • The analysis of 48 randomized controlled trials revealed reductions in fasting insulin and HbA1c levels, indicating improved glycemic control.
  • Both probiotics and synbiotics effectively support glycemic management, particularly in patients with type 2 diabetes and higher baseline BMI.
  • Meta-regression analyses showed no significant link between supplement duration and glycemic change, highlighting consistent efficacy.

Cite This Study

Setayesh et al. (2025) studied this question.

synapsesocial.com/papers/68c24236b210217d647a2c68https://doi.org/10.1007/s12602-025-10644-w
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Also Consider

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  4. 4The Effects of Probiotics Consumption on Blood Pressure, Lipid Profile, Glycemic Indices, and Inflammatory Parameters in Overweight and Obese Adults: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials2025 · 1 citations
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