October 3, 2025Frontiers in NutritionOpen Access

Effects of probiotic supplementation on islet β-cell function in subjects with glucose metabolism disorders: a meta-analysis

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Discussion

Meta-analysis reveals probiotics enhance islet β-cell function in glucose metabolism disorders, suggesting efficacy for high HbA1c individuals.

Probiotic supplementation significantly improved HOMA-β in individuals with glucose metabolism disorders.
In a meta-analysis of 12 RCTs with 907 participants, probiotics showed a mean difference of 3.04.
Sensitivity analysis indicated no significant effect on HOMA-β in low risk of bias studies.
Results highlight the importance of baseline HbA1c levels for probiotic efficacy in enhancing β-cell function.

Xiang et al. (2025) studied this question.

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Meta-analysis reveals probiotics enhance islet β-cell function in glucose metabolism disorders, suggesting efficacy for high HbA1c individuals.