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September 23, 2025Frontiers in Cellular and Infection MicrobiologyOpen Access

Meta-analytical insight on probiotic metabolites and inflammatory markers in diabetes

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Authors

YXYanpeng XieYZY. George ZhengFJFan Jiang

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Overview

Meta-analysis reveals probiotics reduce inflammatory markers in type 1 and type 2 diabetes, suggesting a therapeutic role.

Key Points

  • Probiotic and synbiotic supplementation substantially decreases inflammatory markers like CRP and IL-6.
  • While overall effectiveness was observed, SCFA levels increased significantly, particularly butyrate (SMD = +0.46).
  • The methodology encompassed 46 randomized controlled trials, including a broad sample of 3,580 diabetic patients.
  • The findings underscore the importance of targeted probiotic formulations to alleviate metabolic inflammation, indicating further research is warranted.

Cite This Study

Xie et al. (2025) studied this question.

synapsesocial.com/papers/68d43d83713b0b5dfea7dd6bhttps://doi.org/10.3389/fcimb.2025.1677671
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Probiotic and Synbiotic Supplementation on Glycemic Indices in Adult Individuals with Prediabetes and Type 2 Diabetes Mellitus: A Grade-Assessed Systematic Review and Dose–Response Meta-analysis of RCTs2025 · 14 citations
  2. 2Triple probiotic combination effect on metabolic, oxidative stress, and inflammatory parameters in diabetic population: Systematic review and meta-analysis2025
  3. 3The anti-inflammatory effects of three different dietary supplement interventions2025
  4. 4Effects of probiotic supplementation on islet β-cell function in subjects with glucose metabolism disorders: a meta-analysis2025
  5. 5The effects of probiotic supplementation on cardiometabolic health in patients with prediabetes: a systematic review, meta-analysis, and GRADE assessment2025