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September 5, 2025Frontiers in NutritionOpen Access

The effects of probiotic supplementation on cardiometabolic health in patients with prediabetes: a systematic review, meta-analysis, and GRADE assessment

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Authors

RLR. LiuGWGing Ging Wong

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Overview

Systematic review found probiotic intervention improved HbA1c and HDL-C in prediabetic patients, suggesting therapeutic benefits.

Key Points

  • Probiotic supplementation significantly reduced HbA1c levels, enhancing cardiometabolic health in prediabetics.
  • Results showed a weighted mean difference in HbA1c of −0.11 (p < 0.001), indicating strong efficacy of probiotics.
  • Inclusion of 10 RCTs during the systematic review and meta-analysis strengthened the findings on probiotic effects.
  • GRADE assessment yielded high quality for HbA1c and HDL-C, highlighting the promise of probiotics for prediabetes management.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68c239e5b210217d6477d934https://doi.org/10.3389/fnut.2025.1616476
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Probiotic and Synbiotic Supplementation on Glycemic Indices in Adult Individuals with Prediabetes and Type 2 Diabetes Mellitus: A Grade-Assessed Systematic Review and Dose–Response Meta-analysis of RCTs2025 · 14 citations
  2. 2The Effects of Probiotics Consumption on Blood Pressure, Lipid Profile, Glycemic Indices, and Inflammatory Parameters in Overweight and Obese Adults: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials2025
  3. 3Effects of probiotic supplementation on islet β-cell function in subjects with glucose metabolism disorders: a meta-analysis2025
  4. 4The efficacy of dietary interventions for prediabetes management: An umbrella review of meta-analyses2025
  5. 5Triple probiotic combination effect on metabolic, oxidative stress, and inflammatory parameters in diabetic population: Systematic review and meta-analysis2025