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September 10, 2025Frontiers in ImmunologyOpen Access

Exploring of bladder cancer immune-related genes and potential therapeutic targets based on transcriptomic data and Mendelian randomization analysis

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Authors

ZXZhangxiao XuJYJuan YangYMYanni Ma

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Overview

This analysis uncovers immune-related genes in bladder cancer, indicating novel therapeutic targets and biomarkers.

Key Points

  • Key genes associated with bladder cancer risk were identified, revealing potential biomarkers for therapy.
  • Analysis uncovered 1,391 immune-related genes, with 187 candidate genes showing causal relationships.
  • Differential expression analysis revealed 2,033 bladder cancer-related genes, aiding in identifying therapeutic targets.
  • The study emphasizes the importance of immune-related genes in bladder cancer, suggesting pathways for future research.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/68c24126b210217d6479e43fhttps://doi.org/10.3389/fimmu.2025.1607098
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Also Consider

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  1. 1Comprehensive Mendelian randomization and colocalization analysis of plasma proteomics to identify new therapeutic targets for bladder cancer2025
  2. 2Causal relationship between immune cells and bladder cancer: A bidirectional Mendelian randomization study2025
  3. 3The miRNA–immune axis in bladder cancer: systematic evidence for a new era of immunotherapy precision2025 · 1 citations
  4. 4Revealing the function and mechanism of piRNA-related genes in bladder cancer through single-cell sequencing and methylation analyses and construction of prognostic features based on consensus clustering2025
  5. 5Construction of a gene–metabolite–microbiome regulatory network reveals novel therapeutic targets in bladder cancer through multi-omics analysis2025