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September 10, 2025Current UrologyOpen Access

Revealing the function and mechanism of piRNA-related genes in bladder cancer through single-cell sequencing and methylation analyses and construction of prognostic features based on consensus clustering

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Authors

XSXun SunDJDong‐Dong JiaXSXiaoyun Song

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Overview

This analysis reveals prognostic models using piRNA-related genes in bladder cancer, highlighting single-cell sequencing and methylation effects.

Key Points

  • A prognostic model with 3 piRNA-related genes was developed, indicating improved survival outcomes in bladder cancer patients.
  • Six PIWI-interacting RNA-related genes were identified as significantly associated with bladder cancer progression.
  • Single-cell sequencing confirmed upregulation of MAPK13 in bladder tissues, linking gene expression to cancer mechanisms.
  • Methylation analysis showed decreased levels of INHBA and MAPK13 correlated with expression in bladder cancer tissues.

Cite This Study

Sun et al. (2025) studied this question.

synapsesocial.com/papers/68c24364b210217d647a6790https://doi.org/10.1097/cu9.0000000000000306
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