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September 10, 2025Journal of CancerOpen Access

Comprehensive Mendelian randomization and colocalization analysis of plasma proteomics to identify new therapeutic targets for bladder cancer

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Authors

JZJieming ZuoJCJunhao ChenZTZhi‐Yong Tan

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Overview

Mendelian randomization and colocalization analysis reveals new therapeutic targets in bladder cancer, suggesting novel interventions.

Key Points

  • This study found 199 plasma proteins significantly linked to bladder cancer risk, highlighting therapeutic potential.
  • Five proteins, including NOV and GSTM3, showed robust causal associations, indicating their critical roles in bladder cancer.
  • Analyzing data from UK Biobank and deCODE, two-sample Mendelian randomization was utilized to identify target proteins.
  • These findings underscore potential targets for precision therapy and novel treatment strategies in managing bladder cancer.

Cite This Study

Zuo et al. (2025) studied this question.

synapsesocial.com/papers/68c23f1fb210217d6479515ehttps://doi.org/10.7150/jca.116402
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