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September 10, 2025Annals of MedicineOpen Access

Construction of a gene–metabolite–microbiome regulatory network reveals novel therapeutic targets in bladder cancer through multi-omics analysis

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Authors

ZTZhiyong TanYHYinglong HuangSFShi Fu

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Overview

This multi-omics analysis identifies therapeutic targets and prognostic markers in bladder cancer patients, highlighting gene and microbiome interactions.

Key Points

  • Integration of multi-omics data revealed three key genes and 90 metabolites linked to bladder cancer.
  • The identified molecular clusters showed distinct immune profiles and therapeutic sensitivities, influencing treatment options.
  • Single-cell sequencing highlighted fibroblasts as central regulators, particularly with elevated AHNAK expression.
  • Drug prediction analysis suggested potential compounds targeting key genes, providing insights for precision therapy.

Cite This Study

Tan et al. (2025) studied this question.

synapsesocial.com/papers/68c23c66b210217d64789bc4https://doi.org/10.1080/07853890.2025.2553220
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