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October 1, 2025MedicineOpen Access

Causal relationship between immune cells and bladder cancer: A bidirectional Mendelian randomization study

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Authors

AHAnneng HuCHChunyan HuYLYuhang Lin

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Overview

Mendelian randomization examines associations of immune cell traits with bladder cancer risk, suggesting immunotherapy targets.

Key Points

  • The analysis reveals complex causal relationships between immune cell traits and bladder cancer risks.
  • Sixteen immune traits were identified, five of which significantly increased risk, while eleven offered protection.
  • Mendelian randomization employed inverse variance weighting, MR-Egger, and sensitivity analyses to ensure robustness.
  • The findings highlight new potential immunotherapy targets for bladder cancer prevention and treatment.

Cite This Study

Hu et al. (2025) studied this question.

synapsesocial.com/papers/68dd91d5fe798ba2fc499122https://doi.org/10.1097/md.0000000000044268
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