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September 10, 2025npj Metabolic Health and DiseaseOpen Access

The metabolic advantage of being young and male in obesity treatment outcomes in mice

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Authors

ADAmanda S. DirnbergerERElen Yanina Aguirre RodríguezEAElias Carlos Aguirre-Rodriguez

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Overview

This study demonstrates improved weight loss in young male mice, suggesting age and sex significantly influence obesity outcomes.

Key Points

  • Young male mice exhibit better weight loss outcomes, linked to enhanced WAT mobilization and gene expression.
  • Greater surgical weight loss correlates with changes in the IL17 inflammatory signaling pathway and carbohydrate metabolism.
  • Older age negatively impacts WAT mobilization and transcriptomic plasticity, leading to poorer obesity treatment outcomes.
  • Findings emphasize the need for considering age and sex in obesity treatment research and outcomes.

Cite This Study

Dirnberger et al. (2025) studied this question.

synapsesocial.com/papers/68c23f1fb210217d64795538https://doi.org/10.1038/s44324-025-00065-2
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