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September 5, 2025Gene & Protein in DiseaseOpen Access

Epigenetic regulation role of SUV420H in sexual dimorphism of adipose tissue and obesity

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Authors

CAC AsteriaRCRoberta CacciaAGAlessandro Giovanelli

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Overview

Observational analysis reveals differing SUV420H impacts on PPAR-gamma in adipose tissue, suggesting significant sexual dimorphism.

Key Points

  • SUV420H proteins significantly influence PPAR-gamma activity, impacting obesity risk differently between sexes.
  • Experimentation in mice shows a clear sex-specific difference in diet-induced obesity resistance linked to SUV420H expression.
  • Gene expression analysis indicates a notable inverse relationship between SUV420H and PPAR-gamma expression in obese females.
  • Findings suggest that SUV420H may play a crucial role in regulating metabolic function in relation to obesity.

Cite This Study

Asteria et al. (2025) studied this question.

synapsesocial.com/papers/68c23966b210217d6477c3d3https://doi.org/10.36922/gpd.8441
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