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July 23, 2025PeerJOpen Access

The role of macrophages in renal fibrosis and therapeutic prospects

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Authors

DNDi NiuJYJun YangDHDan He

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Overview

Review reveals macrophages influence renal fibrosis in chronic kidney disease, suggesting new therapeutic targets.

Key Points

  • Macrophages play a crucial role in regulating renal fibrosis through their dynamic phenotypic transitions.
  • Research highlights the essential relationship between macrophages and chronic kidney disease (CKD) development.
  • Advanced techniques like single-cell RNA sequencing unveil important mechanisms in macrophage biology.
  • Targeting specific macrophage functions may provide innovative therapeutic approaches for treating renal fibrosis.

Cite This Study

Niu et al. (2025) studied this question.

synapsesocial.com/papers/689a0621e6551bb0af8cdca2https://doi.org/10.7717/peerj.19769
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