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September 20, 2025Frontiers in ImmunologyOpen Access

The multifaceted role of macrophages in kidney physiology and diseases

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Authors

YMYiyangzi MaFYFanli YangJYJingjuan Yang

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Overview

This review explores macrophages' roles in kidney inflammation and fibrosis, indicating their therapeutic potential.

Key Points

  • Macrophages are essential for kidney physiology, regulating inflammation and tissue repair during injury.
  • These immune cells exhibit diverse functions, with recent advances in single-cell analysis revealing distinct macrophage subsets.
  • During acute kidney injury, macrophages contribute to inflammation, but their dysregulation can lead to chronic kidney disease.
  • Targeting macrophage activity may offer new therapeutic strategies for managing kidney diseases and associated fibrosis.

Cite This Study

Ma et al. (2025) studied this question.

synapsesocial.com/papers/68d439fa713b0b5dfea79ce2https://doi.org/10.3389/fimmu.2025.1642525
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