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August 19, 2025AJP Renal PhysiologyOpen Access

Role of Nuclear Receptors, Lipid Metabolism, and Mitochondrial Function in the Pathogenesis of Diabetic Kidney Disease

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Authors

EHEleni HughesXWXiaoxin X. WangLSLily Sabol

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Overview

Review finds that lipid metabolism and mitochondrial function are critical in diabetic kidney disease, highlighting new therapeutic targets.

Key Points

  • Diabetic kidney disease (DKD) progresses due to factors like lipid metabolism and mitochondrial dysfunction, posing a significant health challenge.
  • Emerging evidence shows novel cell death mechanisms, such as ferroptosis and pyroptosis, are implicated in DKD pathology.
  • This review assesses advances in histopathological and molecular studies, enhancing understanding of DKD's complex mechanisms.
  • Novel therapeutic strategies targeting mitochondrial function and inflammation may provide hope against DKD progression.

Cite This Study

Hughes et al. (2025) studied this question.

synapsesocial.com/papers/68af35ddcf1dd9ea359e9b96https://doi.org/10.1152/ajprenal.00110.2025
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