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September 10, 2025Innovative Journal of PediatricsOpen Access

Tenofovir Disoproxil Fumarate Prevents Mother-to-Child Transmission of Hepatitis B Virus: A Comprehensive Assessment from the Systematic Review and Meta-Analysis

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Authors

LYLi YCYChao YangZCZhiwei Chen

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Overview

Systematic review reveals tenofovir disoproxil fumarate significantly reduces mother-to-child transmission of HBV, indicating effective prevention strategies.

Key Points

  • Tenofovir disoproxil fumarate significantly reduces mother-to-child transmission of hepatitis B virus.
  • The pooled odds ratio suggests a notable reduction in transmission with an OR of 0.38, highlighting TDF's effectiveness.
  • This systematic review and meta-analysis included 43 randomized controlled trials assessing TDF's impact on HBV transmission.
  • The findings support incorporating tenofovir disoproxil fumarate into maternal health programs, emphasizing improved prevention strategies.

Cite This Study

Y et al. (2025) studied this question.

synapsesocial.com/papers/68c23fc3b210217d6479849ehttps://doi.org/10.5812/ijpediatr-157773
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The blocking efficacy and safety of tenofovir disoproxil fumarate tablets on mother-to-child transmission in pregnant women with high serum HBV DNA load: a retrospective cohort study2025
  2. 2Impact of stopping Tenofovir disoproxil fumarate at various times on elevated postpartum ALT levels and breastfeeding in pregnant women with chronic hepatitis B: a prospective observational cohort study2025
  3. 3Modelling Micro‐Elimination: Third‐Trimester Tenofovir Prophylaxis for Perinatal Transmission of Hepatitis B in the Remote Dolpa District of Nepal2025
  4. 4Mother-to-Child Transmission of Hepatitis B Virus Worldwide, Taking Into Account Frequency and Risk Factors: A Systematic Review2025
  5. 5Efficacy and Safety of Entecavir, Tenofovir Disoproxil Fumarate, and Tenofovir Alafenamide Fumarate in Treating Acute-on-Chronic Liver Failure with Hepatitis B Virus: A Network Meta-analysis2025