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September 10, 2025Infectious Diseases and TherapyOpen Access

Efficacy and Safety of Entecavir, Tenofovir Disoproxil Fumarate, and Tenofovir Alafenamide Fumarate in Treating Acute-on-Chronic Liver Failure with Hepatitis B Virus: A Network Meta-analysis

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Authors

JLJia LiuThird Affiliated Hospital of Sun Yat-sen UniversityYBYanzhen BiXMXuefeng MaUniversity of Jinan

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Implication

Network meta-analysis reveals TDF and TAF's advantages in HBV-ACLF management, suggesting improved outcomes.

Key Points

  • TDF showed significantly improved 12-week survival compared to ETV in patients with HBV-ACLF, revealing its efficacy.
  • TAF outperformed ETV in 12-week HBV-DNA clearance, ranking highest in antiviral response among the treatments evaluated.
  • Assessment through network meta-analysis indicates TDF and TAF offer superior outcomes in HBV-ACLF compared to ETV.
  • Renal function assessments showed ETV impacted eGFR more than TAF, highlighting safety differences related to these therapies.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68c23b08b210217d64783487https://doi.org/10.1007/s40121-025-01212-4
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of efficacy and safety of entecavir, tenofovir disoproxil fumarate, and tenofovir alafenamide fumarate treatment in patients with high viral load of hepatitis B virus2025 · 2 citations
  2. 2Comparative effectiveness and safety of tenofovir alafenamide versus tenofovir disoproxil fumarate in patients with HBV-associated decompensated cirrhosis: insights from a retrospective analysis2025 · 3 citations
  3. 3Comparative Efficacy and Renal Safety of Entecavir and Tenofovir Disoproxil Fumarate in the Treatment of Chronic Hepatitis B: A Retrospective Cohort Study From Vietnam2025 · 2 citations
  4. 4Longitudinal changes in estimated glomerular filtration rates in chronic hepatitis B patients treated with Tenofovir Alafenamide vs Entecavir2025 · 3 citations
  5. 5Efficacy and Safety of Tenofovir Alafenamide (TAF) and Tenofovir Disoproxil Fumarate (TDF) Followed by TAF in Chronic Hepatitis B Patients of East Asian Ethnicity Following 5 Years of Treatment2025 · 9 citations