Impact of stopping Tenofovir disoproxil fumarate at various times on elevated postpartum ALT levels and breastfeeding in pregnant women with chronic hepatitis B: a prospective observational cohort study
Prospective observational cohort study investigates TDF impact on elevated ALT levels and breastfeeding rates, suggesting early withdrawal may enhance breastfeeding.
Key Points
Stopping tenofovir disoproxil fumarate at delivery resulted in significantly higher breastfeeding rates compared to later withdrawal.
91 out of 160 patients experienced elevated postpartum ALT levels, with no significant differences across withdrawal timing groups.
Binary logistic regression established that ALT levels at delivery are an independent risk factor for postpartum elevation.
Results imply that early TDF withdrawal may enhance breastfeeding without significantly affecting overall ALT elevation.