Agricultural propiconazole residues promote triazole cross-resistance in Cryptococcus neoformans through ERG11 and efflux pump overexpression

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Resistance to triazole drugs in C. neoformans was induced by propiconazole exposure, affecting treatment outcomes.
Four strains of resistant C. neoformans were isolated from soils treated with propiconazole, indicating its impact.
Propiconazole levels upregulated efflux pump genes and target gene ERG11, promoting resistance development.
Field application of propiconazole, even at recommended doses, may hinder the management of cryptococcosis.

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Analysis shows propiconazole exposure promotes triazole resistance in C. neoformans, suggesting treatment implications.

Yu et al. (2025) studied this question.

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