Population genomics reveals a long-term increase in azole resistance associated with the emerging cluster AZR among Candida tropicalis causing invasive infections
View Full Paper
Ask AI
Bookmark
Share
Key Points
This research aims to understand the rise in azole resistance in Candida tropicalis, particularly related to cluster AZR.
Analyzed azole resistance rates in 911 C. tropicalis isolates collected in 2022-2023.
Conducted longitudinal analysis comparing resistance rates from 2009 to 2022.
Performed population genomic analysis on 604 C. tropicalis isolates to identify genetic factors related to resistance.
Azole resistance rate among isolates reached 43.1% in 2022, a significant increase from 5.7% in 2009.
Candidemia isolates showed a higher resistance rate of 46.1% compared to 39.2% in non-candidemia isolates (p = 0.036).
Cluster AZR, comprising 58.6% of isolates, harbored the ERG11 A395 T mutation linked to increased fluconazole resistance.
Discussion
No takes yet. Share an insight, caveat, or question.
Implication
Randomized trial examines azole resistance in Candida tropicalis, indicating significant public health concerns.