September 10, 2025Deleted Journal

Susceptibility profile of Cryptococcus neoformansto antifungal agentfluconazole

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Research demonstrates fluconazole's effectiveness against Cryptococcus neoformans, suggesting resistance exists among some isolates.

Fluconazole exhibited complete inhibition of C. neoformans at lower concentrations, reinforcing its role as an effective antifungal agent.
At 80 µg/ml, fewer colonies of C. neoformans grew compared to lower fluconazole concentrations, indicating increased efficacy.
Clinical isolate 4832 showed high resistance to fluconazole, highlighting the need for ongoing susceptibility assessments.
The study emphasizes the importance of identifying resistant strains of C. neoformans to enhance antifungal drug effectiveness.

Lugard et al. (2025) studied this question.

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