Unveiling the resistance risk and mechanism of mefentrifluconazole in Colletotrichum scovillei

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Mefentrifluconazole shows a low resistance risk in Colletotrichum scovillei, despite exhibiting cross-resistance with other fungicides.
The study identified a half-maximal effective concentration (EC50) of 0.6924 μg mL−1 for mefentrifluconazole against 102 isolates.
Resistant mutants displayed similar growth and pathogenicity to parental isolates, indicating a potential fitness trade-off.
Analysis revealed overexpression of CYP51 paralogs following mefentrifluconazole exposure, contributing to the resistance mechanism.

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This research evaluates mefentrifluconazole resistance in Colletotrichum scovillei, uncovering mechanisms linked to CYP51 expression.

Shi et al. (2025) studied this question.

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