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September 10, 2025Journal of Cardiovascular Echography

Nitric Oxide Resistance Linked to Vascular and Myocardial Dysfunction in Insulin Resistant Obese Children: A Novel Aortic Strain Study

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Authors

AAAntoine AbdelMassihFMFatma MostafaMYMarianne Edward Yassa

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Overview

Observational analysis shows increased nitric oxide in obese children with insulin resistance, indicating vascular impact.

Key Points

  • Nitric oxide levels are significantly higher in insulin-resistant obese children compared to healthy controls.
  • A strong correlation exists between nitric oxide resistance and vascular dysfunction, impacting myocardial function.
  • Advanced aortic strain rate measures reveal a closer relationship with nitric oxide levels than traditional flow-mediated dilation.
  • Lower aortic strain rates correlate with reduced myocardial functions, especially in the subendocardial layer.

Cite This Study

AbdelMassih et al. (2025) studied this question.

synapsesocial.com/papers/68c23e4fb210217d647921achttps://doi.org/10.4103/jcecho.jcecho_3_25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Effect of Hyperoxia on Nitric Oxide Metabolism in the Skeletal Muscle of Male Type 2 Diabetic Rats2025
  2. 2NADPH Oxidase 1 Mediates Endothelial Dysfunction and Hypertension in a Murine Model of Obesity2026 · 2 citations
  3. 3Investigation of the association between nitric oxide synthase gene variants and NAFLD in adolescents with obesity2025
  4. 4Oral Nitrate Reducing Capacity and Aerobic Fitness is Impaired in Older Individuals with Heart Failure with Reduced Ejection Fraction2025
  5. 5L-citrulline, Arginase Activity, and Nitrate As Potential Nitric Oxide-Related Markers of Subclinical Atherosclerosis in Healthy Middle-Aged Non-smokers: A Cross-Sectional Study2025