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September 10, 2025AJP Heart and Circulatory Physiology

Oral Nitrate Reducing Capacity and Aerobic Fitness is Impaired in Older Individuals with Heart Failure with Reduced Ejection Fraction

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Authors

MSMacy E. StahlEGEmily E. GrammerAWArthur Weltman

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Overview

Findings show lower oral nitrate reducing capacity and exercise tolerance in older adults with heart failure, suggesting a link to cardiovascular dysfunction.

Key Points

  • Oral nitrate reducing capacity was significantly lower in older adults with heart failure compared to healthy controls.
  • The VO2peak levels were lower in heart failure patients at 15.17 compared to 24.25 ml/kg/min in controls, indicating impaired exercise capacity.
  • A correlation exists between oral nitrate reducing capacity and VO2peak, suggesting potential implications for exercise tolerance.
  • Findings indicate the need for larger studies to confirm the link between oral nitrate reducing capacity and functional exercise capacity in heart failure patients.

Cite This Study

Stahl et al. (2025) studied this question.

synapsesocial.com/papers/68c23cf6b210217d6478be25https://doi.org/10.1152/ajpheart.00567.2025
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Decreased Endogenous Nitric Oxide Production in Patients with Acute Decompensated Heart Failure with Preserved Ejection Fraction2025
  2. 2Systematic review and meta-analysis of nitrates/nitrites in patients with heart failure or pulmonary hypertension2025
  3. 3The acute effects of exercise intensity and inorganic nitrate supplementation on the Buckberg ratio in postmenopausal females2026
  4. 4The Effects of Chronic Nitrate Supplementation with Resistance Training on Skeletal Muscle Mitochondrial and Redox Markers in Older Adults2025
  5. 5The Impact of Inorganic Nitrate on Endothelial Function: A Systematic Review of Randomized Controlled Trials and Meta-analysis2025