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September 10, 2025Endocrinology Diabetes & MetabolismOpen Access

The Effect of Hyperoxia on Nitric Oxide Metabolism in the Skeletal Muscle of Male Type 2 Diabetic Rats

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Authors

MMMohammad Vaez MousaviSJSajad JeddiRNReza Norouzirad

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Overview

Observational analysis discovered hyperoxia reduces nitric oxide availability in skeletal muscle, indicating its role in type 2 diabetes treatment.

Key Points

  • Hyperoxia decreased nitric oxide bioavailability in skeletal muscle of type 2 diabetic rats.
  • Rats exposed to hyperoxia had 38% lower lactate and 23% lower nitric oxide metabolites in skeletal muscle.
  • Analysis included rats induced with type 2 diabetes via high-fat diet and streptozotocin exposure.
  • These findings suggest potential side effects of oxygen therapy on nitric oxide metabolism in type 2 diabetes.

Cite This Study

Mousavi et al. (2025) studied this question.

synapsesocial.com/papers/68c2404eb210217d64799d48https://doi.org/10.1002/edm2.70090
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