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September 18, 2025Journal of Pediatric Endocrinology and Metabolism

Investigation of the association between nitric oxide synthase gene variants and NAFLD in adolescents with obesity

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Authors

SHSevde HasanoğluİKİbrahim KandemirYOYasemin Oyacı

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Overview

Cross-sectional study reveals nitric oxide synthase variants' role in NAFLD among obese adolescents, suggesting underlying genetic influences.

Key Points

  • The study found that iNOS rs1060826 variant may impact blood pressure regulation in adolescents with NAFLD.
  • Genotypes of nitric oxide synthase variants were compared in 104 obese adolescents and 64 healthy controls.
  • The eNOS gene variant-TT was associated with higher insulin resistance in adolescents diagnosed with NAFLD.
  • Findings highlight the potential role of nitric oxide synthase gene variants in the development of NAFLD.

Cite This Study

Hasanoğlu et al. (2025) studied this question.

synapsesocial.com/papers/68d433b0713b0b5dfea73359https://doi.org/10.1515/jpem-2025-0229
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