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September 10, 2025CureusOpen Access

L-citrulline, Arginase Activity, and Nitrate As Potential Nitric Oxide-Related Markers of Subclinical Atherosclerosis in Healthy Middle-Aged Non-smokers: A Cross-Sectional Study

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Authors

NONoriyoshi OginoKOKeiki OginoDNDai Nogimura

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Overview

Cross-sectional study reports associations between circulating nitric oxide markers and arterial stiffness, suggesting dietary interventions.

Key Points

  • Significant negative associations between l-citrulline levels and brachial-ankle pulse wave velocity were found.
  • Arginase activity positively correlated with arterial stiffness in participants with a BMI ≤ 23 years.
  • Plasma nitrate levels showed varying associations with arterial stiffness based on alcohol consumption status.
  • These findings indicate potential dietary targets for preventing early vascular changes in healthy middle-aged adults.

Cite This Study

Ogino et al. (2025) studied this question.

synapsesocial.com/papers/68c23caeb210217d6478a8bchttps://doi.org/10.7759/cureus.91720
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