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September 10, 2025Endocrine Research

Genetic prediction of the relationship between mitochondrial proteins and diabetic polyneuropathy risk: a Mendelian randomization study

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Authors

ZWZixiao WangYHYifang HuYWYongyue Wei

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Overview

Mendelian randomization shows mitochondrial proteins COA3, NFU1, and SARS2 impact diabetic polyneuropathy risk, suggesting potential therapeutic targets.

Key Points

  • Elevated COA3 levels decreased the risk of diabetic polyneuropathy, while NFU1 and SARS2 increased risk.
  • The study used data from FINNGEN, including 1048 cases of DPN and 374,434 controls for analysis.
  • Mendelian randomization methods included IVW, MR-Egger regression, and weighted medians to ensure robustness.
  • These findings highlight mitochondrial proteins as potential targets for diabetic polyneuropathy prevention and treatment.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68c23d3ab210217d6478c400https://doi.org/10.1080/07435800.2025.2557991
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Causal Relationship Between Mitochondrial Characteristics and Inflammatory Bowel Disease and Its Subtypes: Evidence for Mendelian Randomization.2025
  2. 2Mitochondrial DNA Copy Number and Risk of Gestational Metabolic Disorders: A Two‐Sample Mendelian Randomization Study2025
  3. 3Mitochondria-related pathogenic genes in acute and chronic kidney disease: a Mendelian randomization study2026
  4. 4Single-cell and experimental analyses identify mitochondria-related genes Hmgcs2, Nudt5, and Cpt1c in painful diabetic peripheral neuropathy2026
  5. 5Exploring the impact of physical activity and micronutrients on diabetic nephropathy: a subtype-specific genetic correlation and Mendelian randomization study2025