Mendelian randomization reveals a protective link between mitochondrial dna copy number and preeclampsia risk, suggesting its relevance in gestational metabolic disorders.
Key Points
Increased mitochondrial dna copy number shows a significant protective association with preeclampsia risk, with an odds ratio of 0.6262.
The analysis utilized data from over 395,000 individuals, focusing on multiple gestational metabolic disorders.
This study applied a two-sample mendelian randomization approach using genome-wide association study summary statistics for robust analysis.
These insights highlight mitochondrial dna copy number as a potential biomarker for preeclampsia risk assessment and therapeutic strategies.