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September 10, 2025Nutrition & MetabolismOpen Access

Exploring the impact of physical activity and micronutrients on diabetic nephropathy: a subtype-specific genetic correlation and Mendelian randomization study

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Authors

FLFang LiLDL. DangYWYanli Wang

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Overview

Mendelian randomization reveals how physical activity and micronutrient intake influence diabetic nephropathy risk in T1DM and T2DM.

Key Points

  • Genetically predicted physical activity significantly reduced T1DM-associated diabetic nephropathy risk.
  • Mediation analysis indicated body mass index played a role in this protective effect against diabetic nephropathy.
  • Higher levels of vitamin E were associated with decreased diabetic nephropathy risk in T2DM patients.
  • Statistical methods included inverse variance weighted analysis and regression for assessing genetic correlations.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68c23f1fb210217d6479501ehttps://doi.org/10.1186/s12986-025-00980-7
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