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September 10, 2025

Causal Relationship Between Mitochondrial Characteristics and Inflammatory Bowel Disease and Its Subtypes: Evidence for Mendelian Randomization.

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Authors

YCYunxuan CaiHFHancheng FanJZJian-Min Zhao

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Overview

Mendelian randomization reveals causal factors in inflammatory bowel disease, suggesting mitochondrial roles in Crohn's disease.

Key Points

  • Mendelian randomization established a causal link between mitochondrial function and inflammatory bowel disease.
  • Peptide chain release factor 1-like was identified as a causative factor for inflammatory bowel disease.
  • Various statistical tests ensured the validity of results, including heterogeneity and pleiotropy tests.
  • Protective mitochondrial proteins against Crohn's disease were highlighted, including NADH dehydrogenase.

Cite This Study

Cai et al. (2025) studied this question.

synapsesocial.com/papers/68c23b8fb210217d64785419https://doi.org/10.1002/jgh3.70257
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