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July 11, 2026Renal FailureOpen Access

Mitochondria-related pathogenic genes in acute and chronic kidney disease: a Mendelian randomization study

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Authors

YWYi-Xiang WangTYTongling YuanQWQian Wei

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Overview

Randomized trial identifies mitochondrial gene associations with acute kidney injury and chronic kidney disease, suggesting potential targets for intervention.

Key Points

  • This study aims to investigate the associations between mitochondrial-related genes and the risks of acute kidney injury and chronic kidney disease using Mendelian randomization.
  • Surveyed mitochondrial-related genes using the MitoCarta3.0 database and summary statistics from genome-wide association studies.
  • Employed Mendelian randomization and colocalization analysis to assess gene-disease relationships.
  • Validated findings using kidney cortex-specific eQTL data and single-cell transcriptome data.
  • Identified 174 mQTLs, 64 eQTLs, and 20 pQTLs associated with AKI risk, along with 253 mQTLs, 80 eQTLs, and 23 pQTLs linked to CKD risk.
  • Found 32 common mQTLs, 16 eQTLs, and 9 pQTLs associated with both AKI and CKD.
  • Confirmed ATP23 as a risk factor for both AKI and CKD, and ATAD3B as a modest protective factor for CKD, with OR 0.95, 95% CI 0.90–1.00.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a51df22c18d7f28ca500663https://doi.org/10.1080/0886022x.2026.2698274
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mitochondrial DNA copy number as a genetic determinant of renal function: insights from bidirectional Mendelian randomization2025
  2. 2Identification of Causal Effects of Mitochondrial Dysfunction on the Risk of Multiple Autoimmune Disorders: Multi‐Omics Mendelian Randomization and Colocalization Analyses2025
  3. 3Exploring the common genetic basis of metabolic syndrome-related diseases and chronic kidney disease: insights from extensive genome-wide cross-trait analyses2025
  4. 4Genetic Associations Between Gastrointestinal Diseases and Chronic Kidney Disease: An Integrated Mendelian Randomization and Bioinformatics Analysis.2026
  5. 5Genetic prediction of the relationship between mitochondrial proteins and diabetic polyneuropathy risk: a Mendelian randomization study2025