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July 23, 2025European journal of medical researchOpen Access

Systematic review and meta-analysis of nitrates/nitrites in patients with heart failure or pulmonary hypertension

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Authors

YHYujuan HuangZBZhenghai BaiLWLi Wang

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Overview

Systematic review shows nitrates improve cardiac function and hemodynamics in heart failure and pulmonary hypertension patients, suggesting clinical benefits remain limited.

Key Points

  • Nitrates significantly improved cardiac function during exercise, increasing stroke volume by 0.86 mL and cardiac output by 0.57 L/min.
  • At rest, nitrates reduced systolic blood pressure by 0.36 mmHg and diastolic blood pressure by 0.19 mmHg in heart failure and pulmonary hypertension patients.
  • Fourteen trials involving 469 patients were analyzed using a random-effects model to assess nitrite effects on cardiac health.
  • These findings indicate nitrates help manage resting hemodynamic overload, although benefits for exercise capacity are limited.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/689a0621e6551bb0af8cdb81https://doi.org/10.1186/s40001-025-02916-6
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Also Consider

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  5. 5Decreased Endogenous Nitric Oxide Production in Patients with Acute Decompensated Heart Failure with Preserved Ejection Fraction2025