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July 19, 2025Nutrition ReviewsOpen Access

The Impact of Inorganic Nitrate on Endothelial Function: A Systematic Review of Randomized Controlled Trials and Meta-analysis

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Authors

BCBegum CelikEMEsther Njeri MuriukiGKGunter G. C. Kuhnle

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Overview

Systematic review shows inorganic nitrate improves endothelial function in patients, indicating cardiovascular benefits.

Key Points

  • Inorganic nitrate was found to improve endothelial function by over 1%, which is significant for cardiovascular health.
  • The meta-analysis included 13 studies assessing flow-mediated dilatation (FMD) as a measure of endothelial function.
  • Acute nitrate consumption led to a greater improvement in FMD (1.93%) compared to chronic use (0.90%).
  • Most studies showed low risk of bias, reinforcing the reliability of findings on inorganic nitrate's effects.

Cite This Study

Celik et al. (2025) studied this question.

synapsesocial.com/papers/689a02c9e6551bb0af8ccf16https://doi.org/10.1093/nutrit/nuaf132
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