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August 22, 2025Journal of Clinical MedicineOpen Access

Decreased Endogenous Nitric Oxide Production in Patients with Acute Decompensated Heart Failure with Preserved Ejection Fraction

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Authors

RFRoman FallsBWBing H. WangSVSara Vogrin

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Overview

Analysis reveals reduced nitric oxide in acute heart failure patients, suggesting endothelial dysfunction may contribute to symptoms.

Key Points

  • Nitric oxide levels were significantly lower in patients with acute heart failure compared to chronic cases, highlighting potential implications for treatment.
  • Plasma nitrite, a key indicator of nitric oxide production, was measured at lower levels in acute heart failure participants (p = 0.022).
  • Assessment included plasma nitrite and nitrate concentrations with other markers like arterial stiffness to investigate endothelial function.
  • Further research is needed to explore the role of nitric oxide in heart failure with preserved ejection fraction and treatment options.

Cite This Study

Falls et al. (2025) studied this question.

synapsesocial.com/papers/68af735d7567bf4f94fece89https://doi.org/10.3390/jcm14175928
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Oral Nitrate Reducing Capacity and Aerobic Fitness is Impaired in Older Individuals with Heart Failure with Reduced Ejection Fraction2025 · 4 citations
  2. 2Dysregulated Protein <i>s</i> -Nitrosylation Promotes Nitrosative Stress and Disease Progression in Heart Failure With Preserved Ejection Fraction2025
  3. 3Systematic review and meta-analysis of nitrates/nitrites in patients with heart failure or pulmonary hypertension2025
  4. 4The Impact of Inorganic Nitrate on Endothelial Function: A Systematic Review of Randomized Controlled Trials and Meta-analysis2025 · 8 citations
  5. 5Influence of Hypoxia on Nitric Oxide Synthase Activity and Gene Expression in Children With Congenital Heart Disease2001 · 94 citations