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July 9, 2026Experimental PhysiologyOpen Access

Nitrate-rich beetroot juice attenuates Buckberg ratio decline following high-intensity exercise in postmenopausal women.

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Why the study?

Does inorganic nitrate supplementation improve the Buckberg ratio following exercise in postmenopausal females?

Population

24 postmenopausal females, mean age 60 ± 5 years, BMI 27.5 ± 5.9 kg/m2, 10 ± 5 years postmenopausal, peak…

Comparison

Nitrate-rich beetroot juice for ~2 days, with a… vs Nitrate-depleted placebo for ~2 days, with a…

Design

RCT, randomized design, double-blind

Follow-up

3 hours post-exercise

Key result

Nitrate-rich beetroot juice attenuated the decline in the Buckberg ratio following high-intensity exercise in postmenopausal females (P<0.001), but not after moderate-intensity exercise.

Authors

CDCassandra C. DerellaAHAustin C. HogwoodJZJoaquin Ortiz de Zevallos

Discussion

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Member takes

Overview

May support high-intensity exercise for perfusion in PMFs; leaves open outcome benefits in trials.

Key Points

  • This research aims to investigate how exercise intensity and inorganic nitrate affect the Buckberg ratio in postmenopausal females.
  • 24 postmenopausal females underwent high-intensity and moderate-intensity exercise after nitrate-rich juice or placebo consumption.
  • The Buckberg ratio was measured using pulse wave analysis at rest and post-exercise over 3 hours.
  • Plasma levels of nitrate and nitrite were assessed pre- and post-supplementation.
  • Buckberg ratio declined significantly after moderate-intensity and high-intensity exercise (P < 0.001).
  • Inorganic nitrate supplementation attenuated the decline after high-intensity exercise (P < 0.001), but not after moderate-intensity.
  • Plasma nitrate and nitrite levels increased significantly with supplementation (P < 0.001).

Study Design

Type

RCT (n=24)

Blinding

double-blind

Randomization

randomized

Structured PICO

Does inorganic nitrate supplementation improve the Buckberg ratio following exercise in postmenopausal females?

P
Population
24 postmenopausal females (mean age 60 years) evaluated for the effects of nitrate-rich beetroot juice versus placebo on the Buckberg ratio following exercise.
I
Intervention
Nitrate-rich beetroot juice (inorganic nitrate supplementation) for ~2 days, with a final dose 2 h before testing, followed by calorically matched high-intensity exercise (HIE), moderate-intensity exercise (MIE), and non-exercise control (CON).
C
Comparator
Nitrate-depleted placebo for ~2 days, with a final dose 2 h before testing, followed by the same exercise and control conditions.
O
Outcome
Buckberg ratio (ratio of diastolic to systolic pressure-time integrals) measured at rest and every 30 min for 3 h following exercise and control conditions.surrogate

Main Result

p-value: p=<0.001

Cite This Study

Derella et al. (2026) conducted an RCT in Postmenopausal females (n=24). Nitrate-rich beetroot juice (BRJ) vs. Nitrate-depleted placebo (PL) was evaluated on Buckberg ratio (p=<0.001). Nitrate-rich beetroot juice attenuated the decline in the Buckberg ratio following high-intensity exercise in postmenopausal females (P<0.001), but not after moderate-intensity exercise.

synapsesocial.com/papers/6a4f3a702b81a944af574bd7https://doi.org/10.1113/ep093920
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dietary nitrate supplementation suppresses sympathetic neural responses to mechanoreflex activation during static handgrip exercise in postmenopausal women2025
  2. 212-week nitrate-rich beetroot extract supplementation improves lower limb vascular function and serum angiogenic potential in postmenopausal women2025
  3. 3Effects of 12-Week Dietary Nitrate Supplementation with Resistance Training on Skeletal Muscle and Vascular Outcomes and in Older Adults2025
  4. 4Oral Nitrate Reducing Capacity and Aerobic Fitness is Impaired in Older Individuals with Heart Failure with Reduced Ejection Fraction2025 · 4 citations
  5. 5The Effects of Chronic Nitrate Supplementation with Resistance Training on Skeletal Muscle Mitochondrial and Redox Markers in Older Adults2025