September 10, 2025Open Access

The complex microscopic dynamics of cells in high-density epithelial tissues

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Jammed epithelial tissues display unexpected fluidity, challenging traditional views of their dynamics.
Findings indicate that cell dynamics include sub-diffusive creep and non-Gaussian behavior, revealing stress-driven fluidity.
Cell divisions and extrusions enhance local motion, yet do not globally fluidize the tissue, highlighting dynamic heterogeneities.
The study connects local structural changes with collective cell behaviors, impacting morphogenesis, wound healing, and tumor progression.

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Research uncovers the unexpected fluidity in jammed epithelial tissues, suggesting implications for morphogenesis and wound healing.

Shen et al. (2025) studied this question.

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