September 20, 2025Open Access

Geometry of disordered porous environments regulates cell migration

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Cell migration is influenced by the porous structure of the extracellular matrix, revealing complex dynamics.
Using a cellular Potts model, we show that varying porosity creates distinct motility regimes characterized by 'hopping'.
Our findings highlight porotaxis, where cells preferentially move towards areas of lower porosity, affecting distributions.
Connecting geometry to cell motility could enhance understanding of processes in inflammation, immunity, and cancer.

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Computational modeling demonstrates how porosity influences cell migration dynamics, suggesting implications for tissue organization.

Würthner et al. (2025) studied this question.

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