July 21, 2025

Controlling the morphologies and dynamics in three-dimensional tissues

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Tissue morphology is affected by factors like cell-cell interactions and self-propulsion from cytoskeletal forces.
The model shows distinct tissue phases based on variations in cell sizes and elasticity, indicating diverse behavior.
At low elasticity, tissue behaves as a liquid, while high elasticity leads to glass behavior and crystallization under certain conditions.
Findings suggest controlling cell properties can help design tissues with customizable material characteristics.

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This model demonstrates how tissue morphology varies with cell elasticity and self-propulsion forces, suggesting new design frameworks.

Thirumalai et al. (2025) studied this question.

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