November 28, 2025Cold Spring Harbor Perspectives in Biology

Soft Matter Physics Meets Cell Biology: Transitions of Collective Cell Migration in 3D Environments

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Cell migration is influenced by the extracellular matrix and can adapt through plasticity for functions such as tissue repair.
Cancer metastasis and morphogenesis are part of the broader context of migration modes, with conditions affecting outcomes.
Integrating physical principles of jamming and unjamming assists in predicting behaviors of cells within 3D tissues.
Further exploration of these interactions could reveal new insights into cancer treatment and tissue engineering.

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Implication

Observational analysis shows impact of extracellular matrix on migration modes in cancer and tissue repair, implying plasticity is key to understanding cell behavior.

Cite This Study

Zegers et al. (2025) studied this question.

synapsesocial.com/papers/6928f106a65b730b9ea79c30 https://doi.org/10.1101/cshperspect.a041794

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Implication

Observational analysis shows impact of extracellular matrix on migration modes in cancer and tissue repair, implying plasticity is key to understanding cell behavior.

Soft Matter Physics Meets Cell Biology: Transitions of Collective Cell Migration in 3D Environments

Key Points

Discussion

Implication

Cite This Study

Soft Matter Physics Meets Cell Biology: Transitions of Collective Cell Migration in 3D Environments

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider