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September 10, 2025Frontiers in ImmunologyOpen Access

Mesenchymal stem cells enhanced with SeNPs protection against CLP induction associated with liver injury are mediated via antioxidant, anti-inflammatory, and immunomodulatory activities

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Authors

AAAbdul AleemMEManal F. El‐KhadragyAMAhmed E. Abdel Moneim

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Overview

Treatment with MSCs enhanced by selenium nanoparticles significantly improves liver function in sepsis models, suggesting new therapeutic avenues.

Key Points

  • MSC treatment with selenium compounds significantly reduced liver injury markers and oxidative stress.
  • Increased levels of antioxidants were observed alongside decreased pro-inflammatory cytokines in treated groups.
  • Selenium-enhanced MSCs improved hepatic tissue structure and function through immunomodulatory activity.
  • Histopathological analysis demonstrated restoration of liver architecture following treatment with enhanced MSCs.

Cite This Study

Aleem et al. (2025) studied this question.

synapsesocial.com/papers/68c23caeb210217d64789e32https://doi.org/10.3389/fimmu.2025.1602994
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Also Consider

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  1. 1Additive Effects of Mesenchymal Stem Cell-Conditioned Medium and Silymarin in Carbon Tetrachloride-Induced Liver Injury in Rats2025
  2. 2Mitigation of sepsis-induced liver injury by Clemastine via modulating GSDMD/NLRP-3/Caspase-1/NF-κB signalling pathways2025
  3. 3Effects of Different Forms of Selenium in Human Umbilical Cord Mesenchymal Stem Cells2025
  4. 4Selenomethionine Attenuates Sepsis-Induced Skeletal Muscle Atrophy by Inhibiting ROS/NLRP3 Signaling2025
  5. 5Selenomethionine alleviates LPS-induced septic kidney injury by regulating mitochondrial dynamics changes2025