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July 31, 2025Research Journal of Biotechnology

Additive Effects of Mesenchymal Stem Cell-Conditioned Medium and Silymarin in Carbon Tetrachloride-Induced Liver Injury in Rats

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Authors

SSSuresh Kumar SrinivasamurthyLBLaxminarayana Kurady BairyVSVijay Paul Samuel

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Overview

Experimental study demonstrates MSCs-CM and silymarin improve liver enzymes in Wistar rats, suggesting novel therapies for liver injury.

Key Points

  • Treatment with high-dose MSC-CM significantly improved liver enzyme levels, reducing toxicity in rats exposed to carbon tetrachloride.
  • Combined therapy involving silymarin and MSCs-CM restored liver architecture, showing the greatest reduction in liver damage.
  • Histopathology findings revealed normal liver structure in control groups while CCl₄-treated rats exhibited severe injury and inflammation.
  • This research highlights the potential of MSCs-CM in liver injury, indicating a promising supportive therapy in combination with silymarin.

Cite This Study

Srinivasamurthy et al. (2025) studied this question.

synapsesocial.com/papers/68af2d76cf1dd9ea359e53b5https://doi.org/10.25303/209rjbt0106
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mesenchymal stem cells enhanced with SeNPs protection against CLP induction associated with liver injury are mediated via antioxidant, anti-inflammatory, and immunomodulatory activities2025
  2. 2The Possible Hepatoprotective Effects of Azilsartan against Carbon Tetrachloride CCl4 - Induced Liver Fibrosis in Male Rats in Comparison with Silymarin: ''in vivo Study''2025
  3. 3Assessment of hepatoprotective activity of coded plant (222) leaf ethanolic extract against carbon tetrachloride-induced hepatotoxicity in Wistar rats – Part IV2017
  4. 4Potential restorative effect of silymarin on liver histoarchitecture on paracetamol-induced in hepatotoxicity, in adult albino rats2025
  5. 5Effects of Silymarin Combined with Herbal Medicine on Th17/Treg Cell Imbalance and Inflammatory Response in Patients with Nonalcoholic Fatty Liver Disease: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial2025 · 1 citations