September 10, 2025Frontiers in PharmacologyOpen Access

Selenomethionine alleviates LPS-induced septic kidney injury by regulating mitochondrial dynamics changes

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Selenomethionine treatment significantly reduces inflammation in acute kidney injury associated with sepsis.
In the experimental model, SeMet treatment attenuated oxidative stress and renal damage compared to controls.
This study conducted in male C57BL/6 mice provides insights into the protective mechanisms of selenomethionine.
Mechanistic findings indicate SeMet alters mitochondrial dynamics and influences macrophage polarization toward the M2 phenotype.

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Implication

Experimental model demonstrates that selenomethionine mitigates inflammatory response and oxidative stress in acute kidney injury, suggesting its therapeutic potential.

Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/68c23d81b210217d6478d85a https://doi.org/10.3389/fphar.2025.1606365

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Implication

Experimental model demonstrates that selenomethionine mitigates inflammatory response and oxidative stress in acute kidney injury, suggesting its therapeutic potential.

Selenomethionine alleviates LPS-induced septic kidney injury by regulating mitochondrial dynamics changes

Key Points

Discussion

Implication

Cite This Study

Selenomethionine alleviates LPS-induced septic kidney injury by regulating mitochondrial dynamics changes

Key Points

Discussion

Implication

Cite This Study

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Also Consider