Experimental model shows Clemastine reduces liver injury by modulating NLRP-3 and Caspase-1 pathways in sepsis, indicating potential therapeutic effects.
Key Points
Clemastine effectively mitigates sepsis-induced liver injury in a rat model through specific signaling pathways.
Pretreatment with Clemastine significantly reduced proinflammatory markers like TNF-α and IL-1β in sepsis.
Histopathological analysis confirmed that Clemastine decreased oxidative stress and cellular damage in hepatic tissues.
The findings suggest that targeting NLRP-3 and Caspase-1 could provide a novel approach to prevent septic liver injury.