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September 18, 2025Shock

Selenomethionine Attenuates Sepsis-Induced Skeletal Muscle Atrophy by Inhibiting ROS/NLRP3 Signaling

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Authors

TLTonghan LiXZXuan ZhaoZXZhikai Xu

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Overview

Murine sepsis model shows selenomethionine improves muscle mass and strength, inhibiting NLRP3-mediated inflammation.

Key Points

  • Selenomethionine treatment improved survival and muscle strength in septic mice, indicating protective effects.
  • The study showed that selenomethionine reduced skeletal muscle atrophy by inhibiting the ROS/NLRP3 signaling pathway.
  • Histological and protein analyses revealed decreased inflammatory cytokine levels with selenomethionine treatment.
  • Findings suggest selenomethionine may offer a therapeutic avenue for addressing sepsis-induced muscle injury.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68d433a3713b0b5dfea72cb5https://doi.org/10.1097/shk.0000000000002690
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Selenomethionine alleviates LPS-induced septic kidney injury by regulating mitochondrial dynamics changes2025
  2. 2Sepsis Induces Long‐Term Muscle and Mitochondrial Dysfunction due to Autophagy Disruption Amenable by Urolithin A2025
  3. 3Redox Cascade in Chicken Skeletal Muscle: SELENOT Suppression in Selenium Deficiency Triggers Disulfidptosis via mtROS‐NADPH Dysregulation2025
  4. 4RAGE contributes to persistent sepsis-induced muscle and mitochondrial alterations2025
  5. 5Mesenchymal stem cells enhanced with SeNPs protection against CLP induction associated with liver injury are mediated via antioxidant, anti-inflammatory, and immunomodulatory activities2025