Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
September 10, 2025Journal of Clinical and Nursing ResearchOpen Access

The Mechanism by Which AGE Activates EGFR-mediated Diabetic Kidney Disease Fibrosis by Regulating the Balance of Tyrosine Phosphatase SHP1/SHP2

View Full Paper
Ask AI
Bookmark
Share

Authors

LLLi LiLZLimin ZhangJJJuan Ji

Discussion

Loading...

Member takes

Overview

Animal and in vitro experiments reveal AGEs disrupt SHP1/SHP2 balance, activating EGFR signaling in kidney fibrosis.

Key Points

  • AGEs disrupt the SHP1/SHP2 balance, leading to fibrosis in diabetic kidney disease.
  • A significant activation of the EGFR and TGFβ pathways contributes to renal fibrosis.
  • Animal experiments and in vitro analyses were used to confirm changes in relevant protein expression.
  • The findings suggest a novel mechanism of fibrosis driven by AGEs in diabetic nephropathy.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68c23caeb210217d64789d78https://doi.org/10.26689/jcnr.v9i8.11798
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1AGEs Inducing EPCs Apoptosis via ROS and p38 MAPK/JNK Pathways in Diabetic Vascular Complications2025
  2. 2Targeting the AGEs-RAGE axis: pathogenic mechanisms and therapeutic interventions in diabetic wound healing2025
  3. 3Advanced glycation end products induce inflammaging in periodontal ligament fibroblasts through RAGE/AKT/mTOR/glycolysis pathway2025
  4. 4Aging-driven transcriptional programs in diabetic kidney disease: multi-omics discovery of diagnostic biomarkers and drug-repurposing targets2026
  5. 5Advanced Glycation End Products Promote PGE2 Production in Ca9-22 Cells via RAGE/TLR4-Mediated PKC–NF-κB Pathway2025